It contains the world's largest exhibition of outdoor sculptures by the Antioquian artist Fernando Botero. The master donated 23 monumental works, making this place one of the main landmarks of the city and a symbol of artistic expression. The square, also known as Parque de las Esculturas, has an area of about 7,500 square metres and is surrounded by the Museum of Antioquia and the Rafael Uribe Uribe Uribe Palace of Culture, a must-see for tourists. Location: Downtown Medellín on Carabobo.

Founded in 1881, it was the first museum to open in Antioquia and the second to open in Colombia. More than 5,000 works are exhibited in its halls, covering all historical periods and artistic expressions of Antioquia and Colombia, as well as temporary and travelling exhibitions of national and foreign artists. The artist Fernando Botero is an important patron of the museum, with a permanent collection of 188 paintings, drawings and sculptures in various formats.

Designed and built between 1929 and 1937 by Belgian architect Agustín Goovaerts, this imposing neoclassical Gothic building is part of Medellín's cultural and heritage complex. It is currently the headquarters of the Instituto Antioqueño para la Cultura y el Patrimonio and houses treasures such as the Archivo Histórico de Antioquia, the Fonoteca Departamental Hernán Restrepo Duque, and the Centro de Documentación Musical. In the dome of the palace, events such as "Cinema Dome", an initiative of the Institute to promote reflection and knowledge through the language of film, are held every Tuesday and Thursday at 16:00 hours, and admission is free.

It is one of the ten cathedrals in the world built with fired bricks. It was designed by the French architect Carlos Carré and took 55 years to build. It is the main temple of the Archdiocese of Medellín. Because of its historical value and Romanesque architecture, it has been a National Monument of Colombia since 1982. It also has a small museum of religious art with some 40 paintings and 15 sculptures. Visitors can admire the Spanish stained glass windows, the floral decorations, the pulpit and the marble holy water font.